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_______________________ Pathophysiology The exact mechanism of nerve dysfunction and damage is dependent on its etiology. For patients with nerve entrapment and compression, an inflammatory response is engendered. This results in venous stasis, increased vascular permeability and eventually demyelination. This can result in scar formation and in cases of severe injury, permanent nerve damage. For patients with nerve tension injury, the inflammatory effect is not as severe and demyelination is not a factor. However, neuronal function is impaired. For patients with fixation along the nerve’s course, an injury will be more common because the nerve lacks mobility and is more readily stretched. Also, pelvic floor dysfunction itself may cause pain along the pudendal nerve distribution.
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